Solution:
- Go to Application Management.
- Right Click Application Management Wizard.
- It will open Introduction page -> Choose Configure a List of Applications to manage. And Next.
- Under Application List, Provide Name as PowerShell List, Select 'Prohibited Application' from the Type drop down and choose source as Software Catalog.
- Now add the Application by selecting the Icon of + Sign and then search for PowerShell.
- Click on Search Option and type PowerShell. It will list out Windows PowerShell Application License Unit.

Choose Windows PowerShell and Click on

to Add License Unit. then Click OK.
- Now click Next and Assign some devices to block the PowerShell on those. And click Finish.
And whenever PowerShell gets executed on those assigned devices, It will be blocked with following error message.

How to Hide the Above Prompt on all devices:
- Create Operational rule and Add steps called "Application Monitoring Module Setup".
- Uncheck Popup Window After Application Termination.
- And Now assigned this operational rule to all the devices (which are assigned to the prohibit application).
Once assigned to all devices, it will modify the parameter and will not going to show the pop-up on user's screen once blocked.
For more information about Prohibited application, here is the Doc Link
: Click Here